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Tumor Growth, Circadian Genes, and Radiation Response Epithalon has been evaluated in several experimental oncology models: In rodent tumor models, repeated Epithalon administration has been associated with slower tumor growth kinetics and reduced incidence of metastasis under specific conditions

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The compound interferes with S-adenosylmethionine (SAM) consumption, meaning it touches the same one-carbon methylation pool that governs DNA methylation and neurotransmitter synthesis, a biologically significant off-target risk that is underreported